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Anti-protozoal Effect of Steroid Hormone 20-hydroxyecdysone
Sponsor: Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan
Summary
20-hydroxyecdysone is an ecdysteroid hormone found in invertebrates and plants. 20-hydroxyecdysone exhibits a broad range of biological properties in various in vitro and in vivo models, including anabolic, antioxidant, anti-inflammatory, immunomodulatory, anti-obesity and antidiabetic activities, in addition to acting as neuroprotective and hepatoprotective agent. Ecdysteroids are widely used by athletes as dietary supplements to increase strength and muscle mass during resistance training, to reduce fatigue and to ease recovery. Mhashilkar AS et al. (2016) were revealed anti-parasitic activity of 20-hydroxyecdysone against the human filarial parasites. According to recent searches in academic databases and medical search engines (Google, www.google.com; PubMed, www.ncbi.nlm.nih.gov/pubmed; and Medline, www.medline.com), no studies have been conducted to assess the anti-protozoal activity of 20-hydroxyecdysone. The aim of the study is to assess anti-protozoal activity of 20-hydroxyecdysone in water sports athletes with giardiasis.
Key Details
Gender
MALE
Age Range
18 Years - 27 Years
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2021-01-01
Completion Date
2027-12-31
Last Updated
2025-04-04
Healthy Volunteers
No
Conditions
Interventions
20-hydroxyecdysone Oral
100 mg (one pill) x two times a day orally, 10 consecutive days
Metronidazole Oral
500 mg (one pill) x two times a day orally, 10 consecutive days
Placebo Oral
100 mg (one pill) x two times a day orally, 10 consecutive days
Locations (1)
Research institute of epidemiology, microbiology and infectious diseases
Tashkent, Uchtepa, Uzbekistan