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RECRUITING
NCT04838678
EARLY_PHASE1

Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)

Sponsor: University of Texas Southwestern Medical Center

View on ClinicalTrials.gov

Summary

The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress. The study will also investigate how hypertension and obesity influence the nervous system and vascular function. The study will involve measuring sympathetic nervous system activity and blood flow during common laboratory physiological stress protocols (e.g. hypoxia, exercise), and in response to infusion of drugs that cause vasodilation or vasoconstriction.

Official title: Sympathetic Neural Patterns and Transduction in Obesity-associated Hypertension

Key Details

Gender

All

Age Range

18 Years - 55 Years

Study Type

INTERVENTIONAL

Enrollment

100

Start Date

2021-07-18

Completion Date

2026-08-31

Last Updated

2025-08-24

Healthy Volunteers

Yes

Interventions

DRUG

Neuropeptide Y

intra-arterial infusion of neuropeptide Y

Locations (1)

University of Texas Southwestern Medical Center

Dallas, Texas, United States