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Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)
Sponsor: University of Texas Southwestern Medical Center
Summary
The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress. The study will also investigate how hypertension and obesity influence the nervous system and vascular function. The study will involve measuring sympathetic nervous system activity and blood flow during common laboratory physiological stress protocols (e.g. hypoxia, exercise), and in response to infusion of drugs that cause vasodilation or vasoconstriction.
Official title: Sympathetic Neural Patterns and Transduction in Obesity-associated Hypertension
Key Details
Gender
All
Age Range
18 Years - 55 Years
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2021-07-18
Completion Date
2026-08-31
Last Updated
2025-08-24
Healthy Volunteers
Yes
Conditions
Interventions
Neuropeptide Y
intra-arterial infusion of neuropeptide Y
Locations (1)
University of Texas Southwestern Medical Center
Dallas, Texas, United States