Clinical Research Directory

MR Antagonist and LSD1

Sponsor: Brigham and Women's Hospital

Summary

Lysine specific demethylase-1 (LSD1) is an epigenetic regulator of gene transcription involved in the pathophysiology of elevated blood pressure and likely renal damage in Blacks. This project investigates whether a genetically driven anti-hypertensive approach proves superior in controlling blood pressure and mitigating renal injury in Blacks who carry the risk allele for LSD1 (rs587168). The findings of these investigations may lead to a new approach in treating a subset (\~30%) of the essential hypertension population (Black LSD1 risk allele hypertensives).

Official title: Role of LSD1 in Hypertension in Blacks

Key Details

Conditions

Interventions

Locations (1)