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RECRUITING
NCT04846140
NA

Optimal Non-invasive Brain Stimulation for Peripheral Vision

Sponsor: The Hong Kong Polytechnic University

View on ClinicalTrials.gov

Summary

Glaucoma is a complex disease that can result in progressive vision loss. There are no treatments that restore vision lost to glaucoma. However, recent studies have shown that vision can be improved by non-invasive brain (NIBS) stimulation and visual training. In this study, we aim to compare and find out the optimal non-invasive brain stimulation model (transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), and transcranial random noise stimulation (tRNS)) for improving peripheral vision in glaucoma patients. The proposed treatment is the application of transcranial electrical stimulation (tES) onto the participant's head, with brain stimulation aimed at the Primary Visual Cortex toward the occipital pole. The investigators hypothesize that the tES will enable higher performance in the reading task and secondary measures due to an increase in the cortical excitability of the stimulated brain cells, and tRNS will generate the greatest acute improvement in peripheral vision than either a-tDCS, tACS, or sham stimulation.

Official title: Identify Optimal Non-invasive Brain Stimulation Paradigm for Improving Peripheral Vision

Key Details

Gender

All

Age Range

18 Years - 80 Years

Study Type

INTERVENTIONAL

Enrollment

40

Start Date

2021-11-01

Completion Date

2025-09

Last Updated

2024-10-29

Healthy Volunteers

No

Conditions

Interventions

DEVICE

transcranial electrical stimulation (tES)

Transcranial electrical stimulation (tES) is a form of neuromodulation that uses constant, low direct current delivered via the electrodes on the skull. Three types of tES will be applied in this study, include a-tDCS, tACS, and tRNS. Additionally, sham stimulation will be applied as a placebo-controlled intervention.

Locations (1)

Allen MY Cheong

Hong Kong, China