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Endocrine Disrupting Chemical Exposure and Testicular Cancer
Sponsor: Rigshospitalet, Denmark
Summary
DISRUPT is a Danish nested case-control study that is currently being conducted to explore the impact of prenatal exposure to endocrine disrupting chemicals on testicular cancer risk (including histological sub-groups) with emphasis on the analysis of exposure mixtures. Pregnant mothers provided serum and amniotic fluid at recruitment up to 50 years ago. By registry linkage within highly reliable national population and disease registries cancer cases and matched controls will be identified. Levels of EDCs including DDT, DDE and other organochlorine pesticides, PCBs, PBDEs, PFAS, phthalates and triclosan will be quantified in cases whose sons develop testicular cancer during 40 year follow up and compared to controls.
Official title: Prenatal Exposure to Endocrine Disrupting Chemicals and Risk of Testicular Cancer in Offspring
Key Details
Gender
MALE
Age Range
15 Years - 50 Years
Study Type
OBSERVATIONAL
Enrollment
700
Start Date
2020-06-01
Completion Date
2030-12-31
Last Updated
2021-04-21
Healthy Volunteers
Yes
Conditions
Interventions
Observational
Prenatal maternal exposure to endocrine disrupting chemicals
Locations (2)
Department of Growth and Reproduction, Rigshospitalet
Copenhagen, Denmark
EDMaRC, Rigshospitalet secton 5064
Copenhagen, Denmark