Clinical Research Directory

Inclusion Criteria: * Male or female child * Aged from 1 month to 3 months and a half * Placement of a prosthesis in a patient with isolated upper limb deficiency, type of congenital transverse unilateral amputation of the forearm segment * Socially insured patient, * Patient willing to comply with all study procedures and study duration * Written informed consent from patient's legal guardians Exclusion Criteria: * Children with one or more high risk factors for neurodevelopmental disorders: * Very prematurity (\<32 weeks of amenorrhea \[SA\]) * Premature infants \<37 WA with intrauterine growth retardation (IUGR) or low weight for gestational age (PAG) \<3rd percentile or \<- 2 SD for GA and sex according to national reference curves) * A presumed hypoxo-ischemic encephalopathy with an indication of therapeutic hypothermia * A perinatal arterial cerebrovascular accident (AVC) (diagnosed between the 20th week of fetal life and the 28th day of life including in premature newborns). * Cerebral growth anomalies: microcephaly with cranial perimeter \<- 2 SD at birth verified secondarily or macrocephaly\> + 3 SD for the term (persisting after a second measurement). * A family history of severe first-degree neurodevelopmental disorder (brother or sister or parent) * Symptomatic congenital cytomegalovirus infections and other infectious fetopathies: toxoplasmosis, Zika, rubella, etc. * Bacterial and viral herpetic meningoencephalitis * Complex congenital heart disease operated on: transposition of the large vessels; left ventricular hypoplastic syndrome. * Perinatal exposure to a major toxicant: certain antiepileptics (sodium valproate); severe exposure to alcohol and / or with signs of fetal disease. * Major, prolonged and repeated surgery (cardiac, cerebral, abdominal, thoracic). * Exclusion of all deficiency forming part of a polymalformative, vascular syndrome (Poland syndrome), genetic cause ... * Exclusion of all other forms of agenesis (bilateral, longitudinal, persistence of hand remains), * Refusal of consent from one or both parents