Clinical Research Directory

Inclusion Criteria: * ≥ 18 and \<70 years * Performance status, ECOG 0-1 * Histologically proved adenocarcinoma in colon or rectum * BRAF wild-type CRC on primary tumor or liver metastases * High standard oncological surgical resection of the primary tumor * Liver metastases not eligible for curative liver resection confirmed by the validation committee * At least one line (3 months) of chemotherapy * At least 6 months time span from CRC resection and date of being listed on the transplantation list. * At least 8 weeks of tumor control: stable disease or partial response according to RECIST 1.1 criteria * No signs of extra hepatic metastatic disease or local recurrence on CT, MRI and Pet-CT except patients may have \<3 lung lesions all\<15mm resected or treated by radiotherapy or metastatic hilar nodes treated by resection and without recurrence at 3 months from resection or radiotherapy. * Satisfactory blood tests creatinine in normal level, PLT \>60.000/mm3, GB\>2500/mm3 * CEA stable or in decrease * Signed informed consent and expected cooperation of the patients for the treatment and follow up Exclusion Criteria: * Weight loss \>10% the last 6 months * Patient BMI \> 30 * Participation refusal * General contraindication to LT * Other malignancies in the previous 5 years * Pregnancy or breast feeding * Any reason why, in the opinion of the investigator, the patient should not participate