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Screening for Amyloidosis Before Aortic Valve Elective Replacement
Sponsor: Charite University, Berlin, Germany
Summary
Previous studies detected that up to 15% of patients undergoing aortic valve replacement (AVR) for degenerative aortic stenosis have concomitant transthyretin amyloidosis (ATTR) cardiomyopathy (Castano, 2017). The aim of this study is to investigate the effectivity and practicability of a systematic ATTR-Screening in patients undergoing planned AVR. Moreover, we plan to develop a screening algorithm to detect ATTR in aortic stenosis (AS).
Official title: Screening for Amyloidosis Before Aortic Valve Elective Replacement (SAVER)
Key Details
Gender
All
Age Range
40 Years - 99 Years
Study Type
OBSERVATIONAL
Enrollment
1000
Start Date
2021-02-01
Completion Date
2028-03-31
Last Updated
2025-02-12
Healthy Volunteers
No
Conditions
Interventions
The outcome of an intervention is not evaluated, but aortic stenosis and additional amyloidosis are compared.
We aim to compare patients with aortic valve stenosis with and without cardiac amyloidosis.
Locations (1)
Charité - Universitätsmedizin Berlin
Berlin, Germany