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Examining tDCS Effect on Cannabis Use Disorder in Patients With Schizophrenia
Sponsor: Centre Hospitalier Universitaire de Saint Etienne
Summary
Cannabis use disorder is a frequent comorbidity of schizophrenia, associated with increased symptoms and less adherence to therapy. Validated care has limited effectiveness in this population and development of new management strategies seems necessary. Transcranial direct current stimulation (tDCS) has shown beneficial effects in both schizophrenia, substance use disorder and, in a less extent, in nicotine addiction in schizophrenic subjects. It is interesting to test if that 10 sessions of anodal stimulation of the right dorsolateral prefrontal cortex (DLPFC) and cathodal stimulation of the medial prefrontal cortex (MPFC) (by increasing control and modulating reward system), will reduce, in 110 schizophrenic subjects, cannabis consumption, and secondly craving, addiction severity, schizophrenic symptoms and improve global functioning. It is possible that these clinical effects will be associated with changes in certain cognitive functions and cerebral connectivity.
Official title: Examining tDCS Effect on Cannabis Use Disorder in Patients With Schizophrenia A Randomized Controlled Double-blind Exploratory Multicentric Study
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
110
Start Date
2023-02-15
Completion Date
2026-03-01
Last Updated
2025-03-18
Healthy Volunteers
No
Conditions
Interventions
Transcranial direct current stimulation (tDCS) active
Stimulation will be performed using a Neurocan DC-Stimulator Plus with two 7×5 cm sponge electrodes soaked in a saline solution. Electrodes will be placed in accordance with the international 10-20 electrode placement system: the anode over F4 (right DLPFC), the cathode over Fp1 (MPFC). The stimulation level will be set at 2 mA for 20 minutes during stimulation sessions twice a day (separated by at least 3 hours) for 5 consecutive weekdays.
Transcranial direct current stimulation (tDCS) non active
The control group will receive the sham stimulation following the same regimen, using the sham procedure which has been developed by the manufacturer of the tDCS material, allowing sensations to be felt in the scalp which are the equivalent to those of the active stimulation. The same device will be used for both the sham and the active procedures.
Locations (8)
CH Le Vinatier Service universitaire d'addictologie de Lyon
Bron, France
Centre Hospitalier Universitaire Service d'Addictologie et Pathologies Duelles
Clermont-Ferrand, France
CHU de Clermont-Ferrand Service de Psychiatrie
Clermont-Ferrand, France
Service Hospitalo-Universitaire d'Addictologie CHU de Dijon
Dijon, France
CHU Pôle de Psychiatrie Neurologie et Rééducation
La Tronche, France
CH Saint-Cyr-au-Mont-d'Or service de psychiatrie
Saint-Cyr-au-Mont-d'Or, France
Centre Hospitalier Alpes Isère
Saint-Égrève, France
CHU de Saint-Etienne
Saint-Priest-en-Jarez, France