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ACTIVE NOT RECRUITING
NCT04875728
PHASE1

The Impact of an Antibiotic (Cefazolin) Before Surgery on the Microbiome in Patients With Stage I-II Melanoma

Sponsor: M.D. Anderson Cancer Center

View on ClinicalTrials.gov

Summary

This phase I trial investigates the impact of cefazolin before surgery on the microbiome in patients with stage I-II melanoma. Antibiotics, such as cefazolin, given at the time of surgery may cause a significant change in the microbes (like bacteria and viruses) found in the stomach and intestines. This trial may help researchers learn if any changes in microbes affect the body's ability to respond to surgery and cancer.

Official title: Evaluating the Impact of Perioperative Antibiotic Prophylaxis on the Microbiome in Patients With Cutaneous Malignancy

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

20

Start Date

2020-09-08

Completion Date

2027-02-02

Last Updated

2025-11-17

Healthy Volunteers

No

Interventions

DRUG

Cefazolin

Given IV

PROCEDURE

Resection

Undergo standard of care surgical resection

Locations (1)

M D Anderson Cancer Center

Houston, Texas, United States