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The Impact of an Antibiotic (Cefazolin) Before Surgery on the Microbiome in Patients With Stage I-II Melanoma
Sponsor: M.D. Anderson Cancer Center
Summary
This phase I trial investigates the impact of cefazolin before surgery on the microbiome in patients with stage I-II melanoma. Antibiotics, such as cefazolin, given at the time of surgery may cause a significant change in the microbes (like bacteria and viruses) found in the stomach and intestines. This trial may help researchers learn if any changes in microbes affect the body's ability to respond to surgery and cancer.
Official title: Evaluating the Impact of Perioperative Antibiotic Prophylaxis on the Microbiome in Patients With Cutaneous Malignancy
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2020-09-08
Completion Date
2027-02-02
Last Updated
2025-11-17
Healthy Volunteers
No
Conditions
Interventions
Cefazolin
Given IV
Resection
Undergo standard of care surgical resection
Locations (1)
M D Anderson Cancer Center
Houston, Texas, United States