Clinical Research Directory
Browse clinical research sites, groups, and studies.
Tissue Engineering Approaches to Treat COPD
Sponsor: University Hospitals of North Midlands NHS Trust
Summary
The study is a pilot/laboratory study comparing lung tissue from control participants with tissue from COPD participants with a chronic bronchitis or emphysema phenotypes. Tissue will be characterised mechanically and biochemically. Lung cells, including DASCp63/Krt5 with a possible role in disease pathology, will be isolated, expanded in vitro, characterised, and banked. Biomaterials will be selected and tested with regards to mechanical and physical properties and selected for use in the production of TELEs with properties matched to healthy and diseased lung tissue. The resulting TELEs will be tested in an ex vivo tissue culture model to determine the extent of their integration with lung.
Official title: A Tissue Engineering Approach to Improve Lung Function and Clinical Outcome in Patients With COPD
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
30
Start Date
2017-08-31
Completion Date
2025-12-31
Last Updated
2025-02-04
Healthy Volunteers
Not specified
Conditions
Interventions
Patients undergoing standard surgery, excess tissue only will be analysed with patient consent.
Lung samples will be obtained from surplus, healthy margin lung tissue resected from patients with suspected or confirmed lung cancer or from resected tissue from lung volume reduction surgery.
Locations (1)
University Hospitals of North Midlands NHS Trust
Stoke-on-Trent, Staffordshire, United Kingdom