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Additional Treatment for Isolated Local Pancreatic Cancer Recurrence Using Stereotactic Body Radiation Therapy
Sponsor: UMC Utrecht
Summary
A randomized controlled trial, nested within an existing prospective cohort (Dutch Pancreatic Cancer Project; PACAP) according to the 'trials within cohorts' (TwiCs) design in which the effect of additional local ablative therapy compared to current standard of care alone, on survival after recurrence in patients with isolated local pancreatic ductal adenocarcinoma (PDAC) recurrence. The most important secondary endpoint is quality of life. Other secondary endpoints are treatment response, acute and late toxicity, overall survival, progression-free survival, local progression-free survival, distant metastases free survival and reasons for non-eligibility or exclusion.
Official title: A Randomized Controlled Trial on Additional Treatment for Isolated Local Pancreatic Cancer Recurrence Using Stereotactic Body Radiation Therapy
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
174
Start Date
2021-07-05
Completion Date
2026-04
Last Updated
2023-06-18
Healthy Volunteers
No
Interventions
Additional stereotactic body radiation therapy
5 fractions of 8 Gray stereotactic body radiation therapy in addition to standard of care.
Locations (3)
Amsterdam University Medical Center, VUmc
Amsterdam, North Holland, Netherlands
Erasmus University Medical Center
Rotterdam, South Holland, Netherlands
University Medical Center Utrecht
Utrecht, Netherlands