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Effects of Oral Glutamine Supplementation on Insulin Resistance and Functional Intestinal Disorders in Obese Patients.
Sponsor: University Hospital, Rouen
Summary
Obesity, which has a prevalence at 15% in France, is a major public health concern. Altered glycemic control and irritable bowel syndrome (IBS) are frequently observed in obese patients and lead to reduce the quality of life. In the last decades, the role of gut microbiota and intestinal permeability has been underlined in obesity, glycemic control and IBS. Interestingly, experimental and clinical data show that glutamine, an amino acid, is able to maintain or restore intestinal permeability in different conditions. We thus hypothesize that oral glutamine supplementation may restore gut barrier function contributing to improve glycemic control and IBS-symptoms. Our project will thus aim to evaluate the effects of 8 weeks - oral glutamine supplementation on glycemic control and IBS symptoms in obese patients in a blinded randomized controlled trial. Placebo group will received protein powder. 55 obese patients will enrolled in each arm and will received oral glutamine supplementation or protein powder (10g t.i.d.) during 8 weeks. Blood and feces samples and intestinal permeability assays will be performed at baseline (w0), after 8 weeks of supplementation (w8) and then after 8 weeks of a wash-out period (w16).
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
110
Start Date
2023-03-01
Completion Date
2026-06
Last Updated
2026-02-06
Healthy Volunteers
No
Conditions
Interventions
Oral glutamine supplementation
patient will receive oral glutamine supplementation 10 g Ter In Die during 8 weeks
Oral protein powder supplementation
patient will receive oral protein powder supplementation10 g Ter In Die during 8 weeks
Insulin-resistance evaluation
Homeostasic model assessment of insulin resistance test will be performed at baseline, Week 8 and Week 16
Functional intestinal disorders evaluation
Functional intestinal disorders will be measured by the IBS severity score and feces consistency by Bristol scale at baseline, Week 8 and Week 16
Locations (1)
Rouen University Hospital
Rouen, France