Clinical Research Directory

Inclusion Criteria: * Adult male or female (age ≥ 18 years); * Patient requiring root canal treatment or retreatment; * Patient who will need a single visit for the root canal therapy, for a mature molar or second premolar, with or without pre-operative pain * Patient who received information and gave written consent (signed informed consent form); * Subject affiliated to a health insurance system, or is a beneficiary (art. L.1121-11, Code of Public Health, France). Exclusion Criteria: * Pulpotomy or pulpectomy performed at a prior visit; * Tooth with apical calcification (sealer unable to reach the root apex); * Tooth with suspected root perforation; * Immature tooth (too wide root apex requiring an apexification); * Other dental treatment ongoing or scheduled within the study period; * At least one symptomatic tooth among those that are not included in this study * Known hypersensitivity to steroids, local anesthetics, or any component of study medical devices; * Subject using long term anti-inflammatory drugs; * Use of illicit substances during the 48h before the first visit (cannabis, cocaine…); * Presence of any significant medical finding or significant history such as uncontrolled systemic diseases that may impact the safety, the interpretation of the results and/or the participation of the subject in the study according to the opinion of the investigator; * Subject who cannot be contacted in case of emergency (phone number); * Simultaneous participation in another clinical trial or subject still within the exclusion period of a previous clinical trial; * Vulnerable subjects (art. L.1121-5 and L.1122-1-2, Code of Public Health, France; art. 66 of the Regulation (EU) 2017/745 on medical devices)