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Fecal Microbiota Transplantation for Early Clostridioides Difficile Infection
Sponsor: Christian Lodberg Hvas
Summary
Clostridioides difficile (CD) infection (CDI) is a global health threat with an urgent need for new treatment strategies. Faecal microbiota transplantation (FMT) is effective for recurrent Clostridioides difficile infection (CDI), and is currently recommended for multiple (three or more), recurrent CDI infections. The role of FMT earlier in the treatment hierarchy of CDI remains to be determined. In this randomized, double-blinded, placebo-controlled clinical trial, we compare FMT with placebo following standard antibiotic treatment for first or second Clostridioides difficile infection.
Key Details
Gender
All
Age Range
18 Years - 130 Years
Study Type
INTERVENTIONAL
Enrollment
42
Start Date
2021-06-02
Completion Date
2024-12-31
Last Updated
2026-10-16
Healthy Volunteers
No
Interventions
Fecal microbiota transplantion (FMT)
Single donor, fecal microbiota transplantion (FMT) from healthy human donors.
Placebo
Food coloring, water, glycerol
Locations (1)
Aarhus University Hospital
Aarhus N, Denmark