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Nebulized Magnesium Sulfate and Sildenafil for Persistent Pulmonary Hypertension of Newborn
Sponsor: Sohag University
Summary
The aim of this study is to evaluate the effectiveness of nebulized magnesium sulfate combined with sildenafil citrate, compared with sildenafil citrate alone, in treating neonates with severe persistent pulmonary hypertension on mechanical ventilation.
Official title: Effectiveness of Nebulized Magnesium Sulfate Combined With Sildenafil Citrate in Persistent Pulmonary Hypertension of Newborn
Key Details
Gender
All
Age Range
6 Hours - 72 Hours
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2021-06-02
Completion Date
2025-06-01
Last Updated
2024-11-27
Healthy Volunteers
No
Interventions
Magnesium sulfate
Nebulized magnesium sulfate (4 ml of 6.4% solution) every 15 minutes
Sildenafil Citrate
Oral sildenafil citrate at an initial dose of 1 mg/kg, with incremental increases by 0.5 mg/kg every 6 hours till reaching a target dose of 2mg/kg every 6 hours.
Isotonic saline
Nebulized isotonic saline (4 ml) every 15 minutes
Locations (1)
Neonatal Intensive Care Unit, Sohag University Hospital
Sohag, Egypt