Clinical Research Directory
Browse clinical research sites, groups, and studies.
POWER Myocardial Fatigue Study: a Biomechanical Assessment of Contractility of Human Myocardium
Sponsor: University Hospitals Coventry and Warwickshire NHS Trust
Summary
To gain a comprehensive understanding of the biomechanical behaviour of human heart to explore the concept of myocardial fatigue in response to a temporal range of preload, afterload and drug-induced inotropy using in-vitro contractile assays.
Official title: Profiling Biomechanical Responses and Workload of the Human Myocardium to Explore the Concept of Myocardial Fatigue and Reversibility
Key Details
Gender
All
Age Range
18 Years - 85 Years
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2021-08-03
Completion Date
2025-04-30
Last Updated
2024-06-18
Healthy Volunteers
Not specified
Interventions
In-vitro contractile fatigue protocol
Using contractility assays for muscle slices or the work-loop assay for isolated heart cells, the tissue preparation will undergo a series of contraction and relaxation under varying levels of preload, afterload, stimulation frequency and under other experimental conditions such as drug-induced inotropism.
Locations (1)
University Hospitals Coventry and Warwickshire
Coventry, United Kingdom