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RECRUITING

NCT04901975

PHASE1/PHASE2

Fibrosis and the Fontan

Sponsor: Children's Hospital of Philadelphia

View on ClinicalTrials.gov

Summary

The purpose of this study is to non-invasively characterize the fibrotic consequences of single ventricle physiology, its possible solution and effect on lymphatics. This project investigates the response to acute imposition of Fontan hemodynamics by examining the interrelationship between liver and cardiac fibrosis/dysfunction and lymphatic congestion along with a pilot trial of the antifibrotic agent, spironolactone, to prevent these consequences and to determine if MRI can discern these differences. The combination of serum biomarkers and MRI form a powerful non-invasive tool in putting together this complicated web of dysfunction.

Official title: Acute Imposition of Fontan Physiology in The Single Ventricle Patient: Effects on Fibrosis, Function and Drug Intervention

Key Details

Gender

All

Age Range

1 Year - 6 Years

Study Type

INTERVENTIONAL

Enrollment

145

Start Date

2021-02-11

Completion Date

2026-06-30

Last Updated

2025-06-08

Healthy Volunteers

Conditions

Single-ventricle

Interventions

DRUG

Spironolactone

Spironolactone is a mild diuretic. Drug dosage will be those used clinically and per the CHOP formulary: 3 mg/kg/day in divided doses every 6-24 hours; the drug will be weight adjusted every \~0.5 kg with a maximum dosage of 200 mg/24 hours. Maximum single dose is 100 mg. Spironolactone, the aldosterone antagonist to be utilized in Specific Aim 2 of this study, is FDA approved, has been on the market for many years and is routinely administered to all types of children with congenital heart disease including SV patients. The choice of which patient this should be administered to is up to the clinician and their patients and therefore, not all SV patients are on this medication.

Inclusion Criteria: * Single Ventricle (SV) Patients Cohort 1 (Observational Group - no study medication): * Subjects between 1 and ≤ 6 years of age of either gender. * Either single left or single right ventricle. * Subjects who are scheduled to undergo a Fontan operation at CHOP. * Parents signing informed consent. Cohort 1A (formerly part of study drug group who wish continued participation in the observational group): * Subjects who were enrolled in this study in Cohort 2 and are either non-compliant with the medication, no longer want to take the medication, or have an AE that requires them to stop the medication, and patient's family would like to continue participation * Patients were on study medication for 6 weeks or less. * The principal investigator deems it appropriate for the patient to switch to the observational arm. * Patients signing the observational informed consent form. Cohort 1B (observational group - in other studies with intervention): * Subjects between 1 and ≤6 years of age of either gender. * Either single left or single right ventricle. * Subjects who are planned to undergo a Fontan operation at CHOP. * Patients in other interventional studies approved by principal investigator. * Patients signing the observational informed consent form. Cohort 2 (study drug Group - spironolactone): * Subjects between 1 and ≤ 6 years of age of either gender. * Either single left or single right ventricle. * Subjects who are scheduled to undergo a Fontan operation at CHOP. * Parents signing informed consent. Controls * Subjects between 1 and ≤ 6 years of age of either gender * Subjects with normal ventricular function and normal livers who present to CMR for clinical indications and require anesthesia. * Receiving contrast for clinical purposes. No control patient will receive contrast for research purposes. * Parents signing informed consent. Exclusion Criteria: \- Cohort 1 (Observational Group - no study medication): * Subjects with any condition judged by the patient's physician that would cause this trial to be detrimental to the patient. * Any contradiction to a sedated CMR (i.e. presence of a pacemaker). * Patient currently taking spironolactone or eplerenone * Subjects in any study that would preclude participation in the study by altering results Cohort 1A (formerly part of study drug group who wish continued participation in the observational group): * Subjects with any condition judged by the patient's physician that would cause this trial to be detrimental to the patient. * Any contradiction to a sedated CMR (i.e. presence of a pacemaker). * Subjects in any study that would preclude participation in the current study. Cohort 1B (observational group - in other studies with intervention): * Subjects with any condition judged by the patient's physician that would cause this trial to be detrimental to the patient. * Any contradiction to a sedated CMR (i.e. presence of a pacemaker). * Patient currently taking spironolactone or eplerenone * Subjects in any study that would preclude participation in the current study or studies not approved by principal investigator. Cohort 2 (Study Drug Group - Spironolactone): * Subjects with any condition judged by the patient's physician that would cause this trial to be detrimental to the patient. * Any contradiction to a sedated CMR (i.e. presence of a pacemaker). * Patient currently taking spironolactone or eplerenone * Subjects with hyperkalemia or Addison disease; * Subjects on enalapril or other angiotensin receptor blockers * Subjects with a history of hypersensitivity to spironolactone suspension or any component of the formulation * Subjects with a clinically documented diagnosis of severe renal insufficiency (implying estimated glomerular filtration rate (eGFR) \<30 mL/minute/1.73 m2). * Subjects in any study that would preclude participation in the study by altering results Controls * Any condition judged by the patient's physician that would cause this trial to be detrimental to the patient. * Any contradiction to a sedated CMR (i.e. presence of a pacemaker). * Patient currently taking spironolactone, eplerenone or an angiotensin converting the enzyme inhibitor/angiotensin receptor blocker.

Locations (1)

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, United States