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External Nitric Oxide Measurement Through SNO Degradation
Sponsor: Indiana University
Summary
In this study, we aim to explore the feasibility of a novel, noninvasive SNO assay to acquire physiological SNO quantification from various parts of the human body and test this new method of analysis. This study aims to help with the currently cumbersome and invasive procedures used to measure SNOs in the body. The proposed activities do not unnecessarily duplicate previous experiments.
Official title: Does a Flashlight Used to Detect Pet Biological Fluids on Human Skin and Other Surfaces Increase Gas Phase Nitric Oxide Levels?
Key Details
Gender
All
Age Range
1 Day - 75 Years
Study Type
INTERVENTIONAL
Enrollment
150
Start Date
2021-05-10
Completion Date
2026-12-30
Last Updated
2026-02-09
Healthy Volunteers
Yes
Conditions
Interventions
Alonefire SV003 10W 365nm UV Flashlight
Investigator will use a Nitric Oxide Analyzer while attached to a small suction port on the subject's ear lobe to be tested for Nitric Oxide. After getting the baseline assay, the investigator will shine a low-intensity UV Flashlight (Alonefire SV003 10W 365nm UV Flashlight) at the ear lobe for 10 seconds, repeated three times at 20 second intervals, to determine if there is photobleaching. Then the assay will then be performed on the opposite ear lobe. Fifteen minutes after the third UV flashlight exposure, the investigator will collect air from the subject's ear during photolysis into a 20mL glass syringe (once from each ear). Fifteen minutes after the third UV flashlight exposure, the investigator will collect air from the subject's ear during photolysis into a 20mL glass syringe (once from each ear). The subject and the investigator will wear UV goggles during the experiment.
Locations (2)
Riley Hospital for Children
Indianapolis, Indiana, United States
Wells Center for Pediatric Research
Indianapolis, Indiana, United States