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Cancer Predisposition Testing by Family-based Whole-genome Sequencing (WGS) in Every Child With Newly Diagnosed Cancer
Sponsor: Sydney Children's Hospitals Network
Summary
Assessment of the utility of family-based (trio) whole-genome sequencing for cancer predisposition testing in sequential newly diagnosed paediatric and adolescent cancer patients
Official title: Assessment of the Utility of Family-based (Trio) Whole-genome Sequencing for Cancer Predisposition Testing in Sequential Newly Diagnosed Paediatric and Adolescent Cancer Patients
Key Details
Gender
All
Age Range
Any - 21 Years
Study Type
OBSERVATIONAL
Enrollment
270
Start Date
2021-03-08
Completion Date
2028-06-15
Last Updated
2022-11-04
Healthy Volunteers
No
Interventions
Family-based whole genome sequencing
1. Germline whole-genome family-based sequencing and variant identification. 2. Multidisciplinary Meeting case discussion. 3. Recommendation of referral to a Cancer Genetics Clinic for further investigation, follow up and/or genetic counselling. 4. Psychosocial study to analyse the impact of germline sequencing on families.
Locations (3)
John Hunter Children's Hospital
Newcastle, New South Wales, Australia
Sydney Children's Hospital
Sydney, New South Wales, Australia
The Children's Hospital at Westmead
Sydney, New South Wales, Australia