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Virological and Immunological Monitoring in Patients (suspected Of/confirmed With) COVID-19
Sponsor: University Hospital, Ghent
Summary
This study is a prospective, observational multicentric study. The study population entails adult patients hospitalized with a high clinical suspicion of COVID-19 and consists of two study arms (SARS-CoV2- vs. SARS-CoV2+).This combined fundamental research project has a dual goal: on the one hand assessing immunological predisposing factors for severe infection and investigating the immunological impact of SARS-CoV2 infection, on the other hand studying viral characteristics. Furthermore, a substudy will examine the pharmacokinetics and pharmacodynamics of hydroxychloroquine in patients receiving this antiviral treatment (REVIVE susbstudy). To answer these research questions, samples will be collected from patients with a high clinical suspicion of COVID-19, hospitalized at UZ Gent and 2 participating hospitals in Ghent (AZ Maria Middelares en AZ Jan Palfijn).
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
109
Start Date
2020-03-23
Completion Date
2024-09-30
Last Updated
2024-09-19
Healthy Volunteers
No
Conditions
Interventions
Blood draw
8x9mL EDTA tubes. In subjects treated with hydroxychloroquine treatment an extra EDTA tube (4mL) will be collected for the REVIVE substudy.
Bronchoalveolar lavage
Only in case of diagnostic or therapeutic indication.
SARS CoV-2 swabs
Nasopharyngeal, oropharyngeal and nasal swabs
Locations (3)
AZ Jan Palfijn
Ghent, Oost-Vlaanderen, Belgium
AZ Maria Middelares
Ghent, Oost-Vlaanderen, Belgium
UZ Gent
Ghent, Oost-Vlaanderen, Belgium