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The Gender Specific Effect on the Results of Ascending Aortic Replacement
Sponsor: Tomsk National Research Medical Center of the Russian Academy of Sciences
Summary
The aim of our study is to analyze the early and late results in men and women who underwent ascending aortic replacement in antegrade cerebral perfusion (ACP) with mild-to-moderate hypothermic circulatory arrest. Female gender is associated with poorer outcomes after surgical aorta replacement. Data on gender specific differences after ascending aortic replacement are conflicting.
Official title: The Gender Specific Effect on the Results of Ascending Aortic Replacement in Small Ascending Aortic Aneurysm
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
200
Start Date
2013-01-01
Completion Date
2023-07-01
Last Updated
2026-06-24
Healthy Volunteers
No
Conditions
Interventions
Ascending aortic replacement
Surgical access will be performed through a median sternotomy. Ascending aortic repair is performed under conditions of cardiopulmonary bypass (CPB) and MHCA with unilateral ACP via innominate artery with a flow rate of 8-10 ml/kg/min and perfusion pressure of 60-80 mmHg. Once CPB is instituted, the aortic cross-clamp is applied, and the heart is arrested with antegrade cardioplegia. Hemiarch replacement involves resection lesser curve of the aortic arch from the base of the innominate artery (Zone 0) to a point immediately distal to the nadir of the lesser curvature (Zone 3 or Zone 2 if the left subclavian artery was too far).
Locations (1)
Tomsk NRMC
Tomsk, Russia