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ACTIVE NOT RECRUITING

NCT04908202

PHASE3

A Study to Determine the Efficacy and Safety of Deucravacitinib Compared With Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Are Naïve to Biologic Disease-modifying Anti-rheumatic Drugs

Sponsor: Bristol-Myers Squibb

View on ClinicalTrials.gov

Summary

The purpose of this study is to evaluate the efficacy and safety of deucravacitinib versus placebo in participants with active psoriatic arthritis who are naïve to biologic disease-modifying anti-rheumatic drugs. The long term extension period will provide additional long-term efficacy and safety information.

Official title: A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Deucravacitinib in Participants With Active Psoriatic Arthritis Who Are Naïve to Biologic Disease-modifying Anti-rheumatic Drugs

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

670

Start Date

2021-07-13

Completion Date

2027-06-10

Last Updated

2025-10-24

Healthy Volunteers

Conditions

Psoriatic Arthritis

Interventions

DRUG

Deucravacitinib

Specified dose on specified days

OTHER

Placebo

Specified dose on specified days

Locations (183)

Local Institution - 0197

Gilbert, Arizona, United States

Local Institution - 0188

Jonesboro, Arkansas, United States

Local Institution - 0168

Fontana, California, United States

Local Institution - 0199

Fullerton, California, United States

Local Institution - 0038

Sacramento, California, United States

Cohen Medical Centers

Thousand Oaks, California, United States

Local Institution - 0170

Denver, Colorado, United States

Local Institution - 0195

Clearwater, Florida, United States

Local Institution - 0272

Margate, Florida, United States

Local Institution - 0082

Miami Lakes, Florida, United States

Local Institution - 0171

Gainesville, Georgia, United States

Local Institution - 0087

Boise, Idaho, United States

Local Institution - 0080

Chicago, Illinois, United States

Local Institution - 0177

Orland Park, Illinois, United States

Local Institution - 0178

Schaumburg, Illinois, United States

Local Institution - 0083

Lexington, Kentucky, United States

Local Institution - 0042

Hagerstown, Maryland, United States

Local Institution - 0198

Detroit, Michigan, United States

Local Institution - 0201

Springfield, Missouri, United States

Local Institution - 0268

Kalispell, Montana, United States

Local Institution - 0186

Voorhees Township, New Jersey, United States

University Hospitals Cleveland Medical Center-Dermatology

Cleveland, Ohio, United States

Local Institution - 0028

Middleburg Heights, Ohio, United States

Local Institution - 0179

Perrysburg, Ohio, United States

Local Institution - 0182

Oklahoma City, Oklahoma, United States

Local Institution - 0185

Corvallis, Oregon, United States

Local Institution - 0175

Greenville, South Carolina, United States

Local Institution - 0036

Jackson, Tennessee, United States

Local Institution - 0172

Allen, Texas, United States

Local Institution - 0189

Amarillo, Texas, United States

Local Institution - 0032

Dallas, Texas, United States

Local Institution - 0273

Bothell, Washington, United States

Local Institution - 0181

Beckley, West Virginia, United States

Local Institution - 0213

Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

Local Institution - 0054

La Plata, Buenos Aires, Argentina

Local Institution - 0215

Quilmes, Buenos Aires, Argentina

Local Institution - 0046

Córdoba, Córdoba Province, Argentina

Local Institution - 0196

Rosario, Santa Fe Province, Argentina

Local Institution - 0047

San Miguel de Tucumán, Tucumán Province, Argentina

Local Institution - 0194

Buenos Aires, Argentina

Local Institution - 0169

Buenos Aires, Argentina

Local Institution - 0192

Buenos Aires, Argentina

Local Institution - 0193

Mendoza, Argentina

Local Institution - 0220

Phillip, Australian Capital Territory, Australia

Local Institution - 0137

Botany, New South Wales, Australia

Local Institution - 0133

Westmead, New South Wales, Australia

Local Institution - 0132

Woolloongabba, Queensland, Australia

Local Institution - 0211

Hobart, Tasmania, Australia

Local Institution - 0136

Camberwell, Victoria, Australia

Local Institution - 0109

Vitória, Espírito Santo, Brazil

Local Institution - 0001

Salvador, Estado de Bahia, Brazil

Local Institution - 0002

Juiz de Fora, Minas Gerais, Brazil

Local Institution - 0219

Curitiba, Paraná, Brazil

Local Institution - 0214

Curitiba, Paraná, Brazil

Local Institution - 0005

Porto Alegre, Rio Grande do Sul, Brazil

Local Institution - 0108

Santo André, São Paulo, Brazil

Local Institution - 0255

Plovdiv, Plovdiv, Bulgaria

Local Institution - 0248

Sofia, Sofia (stolitsa), Bulgaria

Local Institution - 0253

Burgas, Bulgaria

Local Institution - 0249

Plovdiv, Bulgaria

Local Institution - 0267

Plovdiv, Bulgaria

Local Institution - 0246

Plovdiv, Bulgaria

Local Institution - 0247

Plovdiv, Bulgaria

Local Institution - 0245

Sofia, Bulgaria

Local Institution - 0259

Sofia, Bulgaria

Local Institution - 0250

Varna, Bulgaria

Local Institution - 0261

Viña del Mar, Región de Valparaíso, Chile

Local Institution - 0226