Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Study to Compare the Response to Treatment With Abatacept vs Adalimumab, on Background Methotrexate, in Adults With Early, Seropositive, and Shared Epitope-positive Rheumatoid Arthritis and an Inadequate Response to Methotrexate
Sponsor: Bristol-Myers Squibb
Summary
The purpose of this study is to evaluate the superiority in efficacy of abatacept compared with adalimumab, on background methotrexate, in adults with early, seropositive, and shared epitope-positive rheumatoid arthritis and an inadequate methotrexate response.
Official title: A Randomized, Head-to-head, Single-blind Study to Compare the Response to Treatment With Subcutaneous Abatacept vs Adalimumab, on Background Methotrexate, in Adults With Early, Seropositive Rheumatoid Arthritis Who Have "Shared Epitope" HLA Class II Risk Alleles and Have an Inadequate Response to Methotrexate
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
338
Start Date
2021-09-15
Completion Date
2027-09-01
Last Updated
2025-02-19
Healthy Volunteers
No
Conditions
Interventions
Abatacept
Abatacept SC (125 mg) once weekly
Adalimumab
Adalimumab SC (40 mg) once every 2 weeks
Methotrexate
Methotrexate oral/parenteral maximum tolerated dose (minimum 15 mg and maximum 25 mg weekly)
Locations (75)
Local Institution - 0036
Fullerton, California, United States
Local Institution - 0086
Los Alamitos, California, United States
Local Institution - 0041
Aurora, Colorado, United States
Local Institution - 0058
Cumberland, Maryland, United States
Local Institution - 0038
Hagerstown, Maryland, United States
Local Institution - 0084
Eagan, Minnesota, United States
Local Institution - 0040
Freehold, New Jersey, United States
NYU Langone Ambulatory Care Brooklyn Heights
Brooklyn, New York, United States
Local Institution - 0082
Wilmington, North Carolina, United States
Local Institution - 0127
Portland, Oregon, United States
Local Institution - 0031
Duncansville, Pennsylvania, United States
Local Institution - 0034
Jackson, Tennessee, United States
Local Institution - 0044
Dallas, Texas, United States
Local Institution - 0119
Milwaukee, Wisconsin, United States
Local Institution - 0012
CABA, Buenos Aires, Argentina
Local Institution - 0016
Quilmes, Buenos Aires, Argentina
Local Institution - 0014
San Isidro, Buenos Aires, Argentina
Local Institution - 0057
San Miguel de Tucumán, Tucumán Province, Argentina
Local Institution - 0022
Buenos Aires, Argentina
Local Institution - 0023
Buenos Aires, Argentina
Local Institution - 0015
Buenos Aires, Argentina
Local Institution - 0099
Córdoba, Argentina
Local Institution - 0072
Botany, New South Wales, Australia
Local Institution - 0062
Paramatta, New South Wales, Australia
Local Institution - 0063
Maroochydore, Queensland, Australia
Local Institution - 0102
Woodville South, South Australia, Australia
Local Institution - 0064
Camberwell, Victoria, Australia
Local Institution - 0065
Geelong, Victoria, Australia
Local Institution - 0105
Ivanhoe, Victoria, Australia
Local Institution - 0028
Brno, Czechia
Local Institution - 0025
Prague, Czechia
Local Institution - 0001
Montpellier, France
Local Institution - 0047
Rouen, France
Local Institution - 0035
Strasbourg, France
Local Institution - 0002
Toulouse, France
Local Institution - 0059
Berlin, Germany
Local Institution - 0055
Bonn, Germany
Local Institution - 0091
Freiburg im Breisgau, Germany
Local Institution - 0053
Hamburg, Germany
Local Institution - 0056
Planegg, Germany
Local Institution - 0083
Catania, Italy
Local Institution - 0077
Pavia, Italy
Local Institution - 0078
Perugia, Italy
Local Institution - 0100
Roma, Italy
Local Institution - 0093
Nagoya, Aichi-ken, Japan
Local Institution - 0079
Kitakyushu, Fukuoka, Japan
Local Institution - 0110
Sapporo, Hokkaido, Japan
Local Institution - 0046
Sendai, Miyagi, Japan
Local Institution - 0112
Sasebo, Nagasaki, Japan
Local Institution - 0090
Kawagoe, Saitama, Japan
Local Institution - 0089
Tokyo, Japan
Local Institution - 0010
Tokyo, Japan
Local Institution - 0017
Guadalajara, Jalisco, Mexico
Local Institution - 0117
Guadalajara, Jalisco, Mexico
Local Institution - 0006
Mexico City, Mexico City, Mexico
Local Institution - 0008
Mexico City, Mexico City, Mexico
Local Institution - 0118
San Luis Potosí City, San Luis Potosí, Mexico
Local Institution - 0005
Mérida, Yucatán, Mexico
Local Institution - 0009
Chihuahua City, Mexico
Local Institution - 0020
Torun, Kuyavian-Pomeranian Voivodeship, Poland
Local Institution - 0124
Bydgoszcz, Poland
Local Institution - 0019
Elblag, Poland
Local Institution - 0004
A Coruña, Spain
Local Institution - 0003
Madrid, Spain
Local Institution - 0085
Santander, Spain
Local Institution - 0049
Basel, Switzerland
Local Institution - 0052
Sankt Gallen, Switzerland
Local Institution - 0098
Kaohsiung Niao Sung Dist, Taiwan
Local Institution - 0104
New Taipei City, Taiwan
Local Institution - 0095
Taichung, Taiwan
Local Institution - 0096
Taichung, Taiwan
Local Institution - 0120
Tainan, Taiwan
Local Institution - 0111
Cannock, Staffordshire, United Kingdom
Local Institution - 0060
Hull, United Kingdom
Local Institution - 0114
London, United Kingdom