Clinical Research Directory

Inclusion Criteria: * Aged between 18 - 75 years old * First-time ST-segment elevation myocardial infarction based on the newest ESC guidelines * Timely primary percutaneous coronary intervention within 12 hours from onset * Written informed consent acquired Exclusion Criteria: * Known history of or persistent clinical chronic heart failure prior to randomization * Previous use of ARNI, or intolerance or contraindications to study drugs including ARNI or ACEI * History of significant chronic coronary obstruction and adverse ventricular remodeling * History of any cardiomyopathy, valvular heart disease, congenital heart disease, stent or CABG, or planned open-heart surgery within 3 months * History of hepatic impairment or history of cirrhosis with evidence of portal hypertension * History of chronic renal dysfunction, or eGFR \< 30 ml/min/1.73 m2 * History of malignancy and with a life span less than one year * Patients with a known history of angioedema related to previous ACEIs/ARB therapy. * With contraindication to MRI examination (pacemaker and claustrophobia) or cannot finish breath-holding when lying on the examination bed * Pregnancy or nursing women