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Predictive Biomarkers for Pneumonitis After Chemoradiotherapy and Immunotherapy in Patients With Non-small Cell Lung Cancer
Sponsor: M.D. Anderson Cancer Center
Summary
This study looks at the side effects of chemotherapy and radiation (chemoradiation) followed by immunotherapy in patients with non-small cell lung cancer, with a particular focus on lung inflammation (pneumonitis). By collecting blood, stool and saliva samples, and data from lung function tests, researchers may be able to create a database of information about treatment and side effects in patients with non-small cell lung cancer who are receiving chemoradiation followed by immunotherapy. The information gained from this study may also help researchers find signs of problems with lung function earlier rather than later, since lung function is checked more often than routine care. This may improve how quickly these issues can be treated, and future patients may benefit from what is learned.
Official title: Predictive Biomarkers for Pneumonitis After Chemoradiotherapy and Immunotherapy
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
150
Start Date
2021-01-21
Completion Date
2027-02-02
Last Updated
2026-02-19
Healthy Volunteers
No
Conditions
Interventions
Biospecimen Collection
Undergo collection of blood, saliva, stool, and bronchoalveolar lavage samples
Bronchoscopy with Bronchoalveolar Lavage
Undergo bronchoscopy with BAL
Chemoradiotherapy
Undergo concurrent chemoradiation per standard of care
Computed Tomography
Undergo computed tomography scan
Diagnostic Laboratory Biomarker Analysis
Correlative studies
Immune Checkpoint Inhibitor
Receive CPI per standard of care
Nasal Wash and Collection
Undergo nasal wash
Quality-of-Life Assessment
Ancillary studies
Questionnaire Administration
Ancillary studies
Spirometry
Under lung spirometry tests
Locations (1)
M D Anderson Cancer Center
Houston, Texas, United States