Clinical Research Directory

Inclusion Criteria: * Adults with coronary artery disease (CAD) based on an angiogram \>50% stenosis in any major epicardial vessel or history of myocardial infarction or history of coronary revascularization. * Considered to have stable CAD on optimal medical therapy * 60 to 85 years of age * Men and women (women must be postmenopausal either natural or surgical) * Able to give consent Exclusion Criteria: * Ejection fraction \<50%, unstable angina, recent myocardial infarction within 6 months * Coronary revascularization, including percutaneous coronary intervention and coronary artery bypass graft or thoracic surgery within 6 months. * Stroke, obstructive pulmonary disease, hepatitis B, C, HIV, seizures, or other relevant on-going or recurrent illness * Individuals that have participated in respiratory training within the last 12 months or cardiac rehabilitation within the last 6 months * Uncontrolled hypertension * Use of tobacco products including smoking traditional or e-cigarettes * Use of hormone replacement therapy in women or men (e.g., estrogen, progesterone or testosterone) * Regular aerobic exercise training * Unwilling to stop using mouthwash at least 1 week before the start of the study and during study participation * Unwilling to remain weight stable during study participation