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Catheter-Related Early Thromboprophylaxis With Enoxaparin Studies
Sponsor: Yale University
Summary
The goal of the CRETE Studies is to investigate the newly identified age-dependent heterogeneity in the efficacy of enoxaparin in reducing the risk of central venous catheter-associated deep venous thrombosis in critically ill children.
Official title: Age-dependent Heterogeneity in the Efficacy of Prophylaxis With Enoxaparin Against Catheter-associated Thrombosis in Critically Ill Children
Key Details
Gender
All
Age Range
Any - 17 Years
Study Type
INTERVENTIONAL
Enrollment
258
Start Date
2022-05-11
Completion Date
2026-07-31
Last Updated
2025-06-11
Healthy Volunteers
No
Conditions
Interventions
Enoxaparin
Enoxaparin is a LMWH produced from UFH that exerts its anticoagulant effects by binding to and inducing a conformational change in antithrombin to accelerate the inactivation of factor Xa and thrombin. Age-specified dose of enoxaparin will be administered within 24 hours after insertion of the CVC with the dose subsequently adjusted to pre-specified anti-Xa target.
Locations (22)
Children's of Alabama
Birmingham, Alabama, United States
Arkansas Children's Hospital
Little Rock, Arkansas, United States
Children's Hospital Colorado
Aurora, Colorado, United States
Yale-New Haven Children's Hospital
New Haven, Connecticut, United States
University of Florida -UF Health
Gainesville, Florida, United States
Johns Hopkins All Children's
St. Petersburg, Florida, United States
Children's Hospital of Illinois at OSF Saint Francis Medical Center
Peoria, Illinois, United States
Stead Family Children's Hospital
Iowa City, Iowa, United States
Children's Hospital St. Louis
St Louis, Missouri, United States
Hassenfeld Children's Hospital
New York, New York, United States
New York Presbyterian Hospital
New York, New York, United States
Golisano Children's Hospital
Rochester, New York, United States
Maria Fareri Children's Hospital
Valhalla, New York, United States
UH Rainbow Babies & Children's Hospital
Cleveland, Ohio, United States
Nationwide Children's Hospital
Columbus, Ohio, United States
University of Oklahoma
Oklahoma City, Oklahoma, United States
Penn State Hershey Children's Hospital
Hershey, Pennsylvania, United States
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
Dell Children's Medical Canter
Austin, Texas, United States
UTSW Medical Center; Children's Medical Center of Dallas
Dallas, Texas, United States
Children's Hospital of Richmond
Richmond, Virginia, United States
Children's Hospital Wisconsin
Milwaukee, Wisconsin, United States