Clinical Research Directory

Inclusion Criteria: * Age \>= 18 years * Histological confirmation of pleural mesothelioma * Measurable disease * Eastern Cooperative Oncology Group (ECOG) performance status (PS) =\< 2 * Negative pregnancy test done =\< 14 days prior to registration, for women of childbearing potential only. NOTE: male/female: Must be willing to use birth control for the entire study and must agree to use one of the following birth control methods listed: * Hormonal methods, such as birth control pills, patches, injections, vaginal ring, or implants * Barrier methods (such as a condom or diaphragm) used with a spermicide (a foam, cream, or gel that kills sperm) * Intrauterine device (IUD) * Abstinence (no sex) * Provide written informed consent * Willing to return to enrolling institution for follow-up (during the active monitoring phase of the study) * Willing to provide blood samples for correlative research purposes * Patient has received or is planning to receive ICI for mesothelioma * Patient is planning to receive SBRT (stereotactic body radiation therapy) for mesothelioma Exclusion Criteria: * Any of the following: * Pregnant women * Nursing women