Clinical Research Directory

Inclusion Criteria: * Given informed consent * 18 - 75 years of age * GCS between 6 and 12 at hospital admission. GCS between 3 and 5 at hospital admission can be enrolled if patient was sedated at the accident scene with previous GCS between 6 and 15. * Moderate or severe acute traumatic brain injury * All genders * Brain CT scan with signs of of acute intraparenchymal hemorrhage and/or contusion * Able to receive the first dose of treatment or placebo within 18 hours of brain injury, Exclusion Criteria: * Previous use of biperiden * History of epilepsy (confirmed by patient chart) * History of seizures or use of antiepileptic medication * Pregnancy * Participation in another clinical trial at the time of randomization * History of neoplasia, neurodegenerative diseases; history of stroke, cognitive impairment, benign prostatic hyperplasia, atrioventricular block or any other cardiac arrhythmia, or glaucoma megacolon or mechanical obstruction * Homeless patient