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ROSE for Improved Molecular Marker Testing Via EBUS
Sponsor: Johns Hopkins University
Summary
This research study is being done to compare two ways to conduct bronchoscopic biopsy of lymph nodes and other structures in the chest (i.e. the presence or absence of an on-site cytotechnologist performing a limited microscopic evaluation to provide non-binding feedback on specimen adequacy in real time during the procedure).
Official title: Rapid Onsite Cytopathologic Evaluation for Improved Molecular Marker Testing Via Endobronchial Ultrasound Bronchoscopy - A Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
349
Start Date
2021-05-14
Completion Date
2026-12-31
Last Updated
2025-12-17
Healthy Volunteers
No
Conditions
Interventions
ROSE (presence of cytotech) & liquid prep
Standard of care EBUS will include presence of trained cytotechnologist providing on-site cytopathology feedback to bronchoscopist during the procedure. Sample is liquid.
NO-ROSE (absence of cytotech) & liquid prep
Standard of care EBUS will NOT include presence of trained cytotechnologist providing on-site cytopathology feedback to bronchoscopist during the procedure. Sample is liquid.
ROSE (presence of cytotech) & tissue clot sample
Standard of care EBUS will include presence of trained cytotechnologist providing on-site cytopathology feedback to bronchoscopist during the procedure. Sample is a tissue clot.
NO-ROSE (absence of cytotech) & tissue clot sample
Standard of care EBUS will NOT include presence of trained cytotechnologist providing on-site cytopathology feedback to bronchoscopist during the procedure. Sample is a tissue clot.
Locations (4)
Northwestern Medicine
Chicago, Illinois, United States
Johns Hopkins Bayview Medical Center
Baltimore, Maryland, United States
Johns Hopkins Hospital
Baltimore, Maryland, United States
The Medical University of South Carolina (MUSC)
Charleston, South Carolina, United States