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Dynamic Change and Immune Response to Nasopharyngeal Carriage and Acute Otitis Media Pathogens
Sponsor: Rochester General Hospital
Summary
The investigators seek to conduct a prospective, longitudinal study to identify the dynamic changes in nasopharyngeal (NP) colonization patterns and acute otitis media (AOM) etiology involving antibiotic-resistant Streptococcus pneumoniae (Spn) and Haemophilus influenzae (Hflu).
Key Details
Gender
All
Age Range
6 Months - 36 Months
Study Type
INTERVENTIONAL
Enrollment
320
Start Date
2021-01-01
Completion Date
2026-12-31
Last Updated
2025-07-29
Healthy Volunteers
Yes
Conditions
Interventions
Tympanocentesis
When acute otitis media is diagnosed, local anesthetic applied, small hole placed in eardrum, middle ear fluid extracted.
Nasal Phalangeal Swab and Wash
Nasal phalangeal swab used to retrieve sample. Nasal wash used to retrieve sample.
Blood Draw
Venipuncture
Locations (1)
Rochester General Hospital
Rochester, New York, United States