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Perinatal Covid-19 Infection, NO Pathway, and Minipuberty
Sponsor: University Hospital, Lille
Summary
Some evidence exists that SARS-COV-2 may infect pituitary axis, and therefore may alter hypothalamic function. Whether perinatal COVID-19 is associated with alterations in the maturation of the Hypothalamic-Pituitary-Gonadal (HPG) axis, and specifically with its transient activation occurring during infancy, namely minipuberty, is a major concern. Among the various pathogenic features related to COVID-19, altered minipuberty could be a key factor underlying many multimorbidities later in life, suggesting that they could involve a common causative mechanism that occurs within this short and critical period of time following birth. Altered minipuberty together with NO deficiency seem to be key factors underlying many of these multimorbidities, suggesting that they involve a common causative mechanism that occurs within this short and critical period of time following birth
Official title: Exploratory Multicenter Observational Study to Assess the Outcome of Infants With Perinatal SARS-COV-2 Infection and Its Link With the NO Pathway: the Minipuberty Hypothesis
Key Details
Gender
All
Age Range
Any - 3 Months
Study Type
OBSERVATIONAL
Enrollment
180
Start Date
2022-11-03
Completion Date
2026-11
Last Updated
2023-02-08
Healthy Volunteers
No
Interventions
Inhaled NO
Newborn or young infants (\< 3 months) receiving inhaled NO as part of their treatment for severe respiratory failure
routine care
Patients treated for respiratory failure
Locations (2)
Hop Jeanne de Flandre Chu Lille
Lille, France
Uri-National and Kapodistrian University of Athens
Athens, Greece