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Microbiome and Immunosuppression: The Mission Study
Sponsor: The University of Texas Medical Branch, Galveston
Summary
The purpose of this research is to study immunosuppression drugs, certain foods, and how they can change the microbiome (the natural microorganisms inside the body) of the individual taking the immunosuppressive medications. The study team wants to study how the microbiome affects how the body processes the transplant medication.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
140
Start Date
2020-02-12
Completion Date
2033-01-01
Last Updated
2025-06-15
Healthy Volunteers
No
Interventions
collection of body microbiome
A prospective, observational microbiome study of adult kidney transplant recipients receiving mycophenolate mofetil and tacrolimus maintenance immunosuppression. Participants will be studied post-transplant for mycophenolate pharmacokinetics and microbiome samples collected. Clinically measured tacrolimus trough concentrations will also be evaluated. Associations among mycophenolic acid enterohepatic recycling and metabolite formation, tacrolimus troughs, immunosuppression adverse effects, diarrhea and microbiome will be studied.
Locations (2)
University of Minnesota
Minneapolis, Minnesota, United States
HCMC
Minneapolis, Minnesota, United States