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Effect of Citrate Dialysate on Vascular Calcification
Sponsor: Emory University
Summary
The goal of this study is to determine whether hemodialysis with citrate slows the progression of vascular calcification. Participants will be dialyzed with one of two standard dialysis solutions, one with and one without citrate, for 12 months and then switched to the other solution for 12 months. Vascular calcification will be measured on mammograms that will be performed at 6-month intervals and additional blood samples will be obtained at 6-month intervals.
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
54
Start Date
2021-05-27
Completion Date
2025-03-18
Last Updated
2026-05-05
Healthy Volunteers
No
Conditions
Interventions
Citrate Dialysate
Dialysate is generated during dialysate from two concentrates (acid concentrate and bicarbonate concentrate) mixed with treated water. When used, citrate is provided in the acid concentrate. The acid concentrate with citrate is approved for this use by the FDA and will be used according to standard procedures without altered dialysis machine settings.
Standard Dialysate
Dialysate is generated during dialysate from two concentrates (acid concentrate and bicarbonate concentrate) mixed with treated water. The acid concentrate without citrate is approved for this use by the FDA and will be used according to standard procedures without altered dialysis machine settings.
Locations (4)
Emory Dialysis at Northside
Atlanta, Georgia, United States
Emory Dialysis at Greenbriar
Atlanta, Georgia, United States
Emory Dialysis at North Decatur
Decatur, Georgia, United States
Emory Dialysis at Candler
Decatur, Georgia, United States