Clinical Research Directory

Inclusion Criteria: * Idiopathic Parkinson's disease with III-IV Hoehn-Yahr stage, exhibiting severe gait difficulties and postural instability * With Medtronic DBS implant and receiving medication for Parkinson's disease * Aged 18 to 80 years * Stable medical, physical and psychological condition as considered by the Investigators in accordance with treating physician and treating neurologist. * Must agree to comply in good faith with all conditions of the study and to attend all required study training and visit * Must provide and sign the study's Informed Consent prior to any study-related procedures Exclusion Criteria: * Severe or chronic medical disorder pre-existing PD diagnosis affecting rehabilitation * Active oncological disease requiring heavy treatments and frequent MRI controls * Having an implanted device that is active (e.g., pacemaker, implantable cardiac defibrillator) whose interference with the investigational system's neurostimulator (Activa RC) is not confirmed safe by the CE-mark of the device, or having an indication that might lead to implantation of such device * Inability to follow study procedures, e.g. due to language problems, psychological disorders, dementia as considered by the Investigators in accordance with treating physician and treating neurologist * Hematological disorders with an increased risk of hemorrhagic event during surgical interventions * Life expectancy of less than 12 months * Pregnant or breast feeding * Participation in another interventional study