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PK/PD of Caspofungin in Children Severe Infection
Sponsor: Children's Hospital of Fudan University
Summary
Caspofungin is an anti-fungal drug mainly metabolized by the liver. The pathophysiological status of children with severe infection will affect the metabolism of caspofungin in the body especially in the case of liver dysfunction. There is little metabolism of caspofungin through the kidney and continuous renal replacement therapy and renal function have little influence on the pharmacokinetics of caspofungin. The study aim to investigate PK/PD of caspofungin in children with specific pathophysiological conditions, such as liver insufficiency, hypoproteinemia, ECMO treatment, or sepsis.
Official title: Pharmacokinetics and Pharmacodynamics of Caspofungin in Children Severe Infection
Key Details
Gender
All
Age Range
3 Months - 18 Years
Study Type
OBSERVATIONAL
Enrollment
60
Start Date
2022-10-01
Completion Date
2026-12-01
Last Updated
2026-02-17
Healthy Volunteers
No
Conditions
Interventions
Caspofungin
For children 3 months of age, the recommended dose is 70 mg/m2 for load and then 50 mg/m2 for maintenance, intravenous injection, once daily up to 5 days.
Locations (2)
Children's Hospital of Fudan University
Shanghai, Shanghai Municipality, China
Children's Hospital of Fudan University
Shanghai, Shanghai Municipality, China