Clinical Research Directory

Inclusion Criteria: * Age: 6-65 years old * Diagnosis of persistent asthma * Treatment level at study entry: * For children 6-11 years: Step2 or Step3 of the GINA document * For adolescents and adults 12-65 years: Step2 under daily low-dose inhaled corticosteroids (ICS), Step 3 or Step 4 of the GINA document * Uncontrolled asthma (ACQ-5 \> 1.5) that, according to the physician, does not warrant an immediate step-up of the treatment * History of moderate or severe exacerbations in the twelve (12) months prior to baseline visit Exclusion Criteria: * Use of oral, rectal or parenteral glucocorticosteroids 30 days before enrolment * Treatment with leukotriene receptor antagonist (LTRA) * Treatment with maintenance and reliever therapy (SMART/MART) * Smoking, current or previous with a history of 10 pack-years or more * Documented COPD or other concomitant clinically important diseases or cognitive impairment that, according to the physician, may interfere with the subject's ability or safety to participate in the study * Obesity (for subjects 6-19 years: BMI ≥ 95th percentile; for adults 20-65 years: BMI ≥ 40kg⋅m-2 * For school-age children (6-11 years old): gestational age at birth \< 37 weeks or documented bronchopulmonary dysplasia (BPD) * Prolonged absence from home during the monitoring period (i.e. at recruitment, expected ≥3 consecutive weeks for ≥2 times during the 9- month monitoring period) Subject currently enrolled in other clinical trials related or involving the study of the respiratory system * History of near-fatal asthma * Women who are pregnant, nursing or intending to become pregnant during the time of the study * Absence of health insurance coverage (applies to French centres only)