Clinical Research Directory

Inclusion Criteria: * Can provide informed consent. * Age between 18 and 85 years old * Body Mass Index: 25 ≤ BMI ≤ 40 * Hemoglobin A1c level: 7.5 ≤ HbA1c ≤ 9.5 * Individuals with pre-diabetes and diabetes Type II for at least 1 year (diagnosed by ADA criteria) and up to 20 years * Advanced diabetic complications including neuropathy, nephropathy, retinopathy and other related complications * Stable dose of medications for the previous 3 months * Stable diet and lifestyle for the previous 3 months * Stable medical status (Ex: no myocardial infarction, stroke, major surgery, Exclusion Criteria: * Unable to provide informed consent * Chronic disease (e.g. HIV, Cushing syndrome, CKD, acromegaly, active hyperthyroidism etc.) * Cancer and anticancer treatment in the last 5 years * Psychiatric disorders (that in the eyes of the investigator should exclude the participant) * Any disorder, which in the investigator's opinion might jeopardize subject's safety or compliance with the protocol * Organ (kidney, pancreas, liver) transplant recipients * Pregnancy or lactation * Positive drug screen (opiates, methadone, cocaine, amphetamines, cannabinoids, barbiturates, benzodiazepines, tricyclic antidepressants and alcohol) * Alcoholics or Smokers * Positive screen on HBsAg, anti-HCV or anti-HIV ½ * History of diabetic ketoacidosis or hyperosmolar coma * Subjects with known coronary artery disease or coronary revascularisation * Subjects with previous history of cerebrovascular accident * Subjects with known proliferative retinopathy or previous laser treatment for diabetic retinopathy * Subjects with life-threatening conditions including malignancy * Subjects with known psychiatric conditions including depression * Subjects with significant renal impairment (eGFR\<60ml/min at baseline) or non-diabetic renal disease (e.g. biopsy-proven glomerulonephritis or obstructive uropathy) * Subjects with major physical disability