Clinical Research Directory

Inclusion Criteria: * Voluntarily signed written informed consent according to the rules of Good Clinical Practice (Declaration of Helsinki) and national regulations. * Age ≥ 18 years. * Male patient. * Fit for operation, upon surgeon's discretion. * Isolated penile stricture that requires a multi-stage urethroplasty with dorsal inlay of a graft (upon surgeon's discretion). * Use of oral mucosa as graft material. * Patient is able and willing to comply with protocol. * Prior urethral surgery (dilation, urethrotomy of urethroplasty) is allowed. Exclusion Criteria: * Absence of signed written informed consent. * Age \< 18 years. * Female patients. * Transgender patients. * Patients unfit for operation. * Stricture disease extending beyond the penile urethra or concomitant stricture at a different urethral segment. * Use of graft other than oral mucosa. * Any condition or situation, which, in the investigator's opinion, puts the patient at significant risk, could confound the study results, or may interfere significantly with the patient's participation in the study. * Unwilling or unable to comply with study protocol. * Patients deciding not to undergo the second stage will be excluded post-hoc. * When the surgeon intra-operatively decides to carry out a single-stage procedure after all, the patient will also be excluded post-hoc. * If the surgeon decides that no graft is needed to retubularize the urethra, the patient will also be excluded post-hoc. * If the surgeon decides that a two-stage Bracka repair is needed, where the urethral plate is entirely cut away during the first stage and grafted, the patient will also be excluded post-hoc.