Clinical Research Directory
Browse clinical research sites, groups, and studies.
Early Reperfusion Therapy With Intravenous Thrombolysis for Recovery of VISION in Acute Central Retinal Artery Occlusion
Sponsor: University Hospital Tuebingen
Summary
Non-arteritic, thromboembolic central retinal artery occlusion (CRAO) is an acute neurovascular-ophthalmological emergency which leads to severe and permanent vision loss; no evidence-based therapy does exist. Two recent meta-analyses indicate early intravenous thrombolysis to be beneficial in CRAO. Therefore, the REVISION randomized placebo-controlled interventional trial will investigate intravenous alteplase in CRAO as it is practiced in acute ischemic stroke, i.e. within 4.5 hours after symptom onset. The REVISION observational study will evaluate retinal changes on optical coherence tomography (OCT) in patients within 12 hours of CRAO onset, and the REVISION substudy, which will be conducted adjunct to either the interventional or the observational study, will evaluate the value of the retrobulbar spot sign for prediction of outcome and treatment response.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
422
Start Date
2022-10-10
Completion Date
2026-12-31
Last Updated
2025-04-27
Healthy Volunteers
No
Conditions
Interventions
Tenecteplase (until trial protocol V04: Alteplase)
Intravenous thrombolysis within 4.5 hours of symptom onset
Locations (1)
University Hospital Tuebingen
Tübingen, Germany