Clinical Research Directory

Inclusion Criteria: 1. Male or females \>18 years old ≥ 6months after kidney transplantation; 2. In patients with T2D or PTDM, HbA1c \<12.0%; 3. eGFR ≥30 ml/min/1.73m\^2 (as per the CKD-EPI equation); 4. BMI ≤45kg/m\^2; 5. Blood pressure ≤160/90 and ≥90/60 at screening. Exclusion Criteria: 1. Diagnosis of type 1 diabetes; 2. Presence of severe peripheral vascular disease (i.e. prior amputation, gangrene, non-healing ulcer or ischemic rest pain); 3. Presence of acute coronary syndrome, stroke or transient ischemic attack in the 3 months prior to screening; 4. Prior episode of graft pyelonephritis in the 1 month prior to screening; 5. Episode of acute graft rejection in the 3 months prior to screening; 6. Initiation of a new immunosuppressive agent or discontinuation of an immunosuppressive agent in the 1 month prior to screening; 7. Untreated urinary or genital tract infection; 8. Severe hypoglycemia within 3 months of screening, or hypoglycemia unawareness; 9. Pre-menopausal women who are nursing, pregnant, or of child-bearing potential and not practicing an acceptable method of birth control; 10. Participation in another trial with an investigational drug within 30 days of informed consent; 11. Alcohol or drug abuse within 3 months prior to informed consent that would interfere with trial participation; 12. Any ongoing clinical condition that would jeopardize subject safety or study compliance based on investigator judgement. 13. Patients currently using antipsychotic medications. 14. Use of SGLT2 inhibitors within 1 month of starting the study.