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RECRUITING
NCT04966351
NA

Countermeasures to Circadian Misalignment

Sponsor: Colorado State University

View on ClinicalTrials.gov

Summary

Insufficient sleep and circadian misalignment are independent risk factors for the development of obesity and diabetes, yet few strategies exist to counter metabolic impairments when these behaviors are unavoidable. This project will examine whether avoiding food intake during the biological night can mitigate the impact of circadian misalignment on metabolic homeostasis in adults during simulated night shift work. Findings from this study could identify a translatable strategy to minimize metabolic diseases in populations that include anyone working nonstandard hours such as police, paramedics, firefighters, military personnel, pilots, doctors and nurses, truck drivers, and individuals with sleep disorders.

Official title: Time-restricted Feeding to Mitigate Metabolic Impairments During Circadian Misalignment

Key Details

Gender

All

Age Range

18 Years - 35 Years

Study Type

INTERVENTIONAL

Enrollment

32

Start Date

2021-07-07

Completion Date

2026-06-30

Last Updated

2025-07-24

Healthy Volunteers

Yes

Interventions

BEHAVIORAL

Time-restricted feeding

Each subject will participate in both conditions (CM and CM+TRF)--one in which food is allowed during the nighttime period and one in which food will be restricted to the daytime only. Food intake will be matched across conditions and designed to keep participants weight stable.

BEHAVIORAL

Circadian Misalignment

Healthy lean subjects will undergo circadian misalignment induced using a simulated night shift-work protocol in both conditions of the study. Each condition will last approximately 6 days.

Locations (1)

Colorado State University

Fort Collins, Colorado, United States