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Phase-dependent Evaluation of Motor Cortex Excitability With TMS in Stroke
Sponsor: University of Minnesota
Summary
The purpose of this study is to investigate the effects of transcranial magnetic stimulation (TMS) on motor cortex excitability in individuals who have suffered stroke and to study the influence of the phase of the oscillatory rhythm (mu frequency) on motor excitability in stroke individuals.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
24
Start Date
2021-10-01
Completion Date
2025-10-01
Last Updated
2026-09-14
Healthy Volunteers
Yes
Conditions
Interventions
Transcranial magnetic stimulation (TMS)
TMS will be administrated with a Magstim 70mm figure-8 coil allowing for focal stimulation. Single-pulse TMS will be applied at different phases, (0, 90, 180, 270 degrees - 4 stimulation conditions), of the ongoing mu-rhythm. Positioning of the TMS coil will be neuronavigated based on individual MRI scans. Stimulation will be applied in a closed-loop fashion while the participant is at rest and their EEG activity is recorded.
Locations (1)
University of Minnesota
Minneapolis, Minnesota, United States