Clinical Research Directory

Inclusion Criteria: * 18 years of age or older: * with at least 20 permanent natural teeth, excluding crowns; * affiliated to a social security system; * having received information about the protocol and having given their free, informed and written consent. Exclusion Criteria: * with periodontitis in the month prior to inclusion; * with significant carious lesions deeply modifying the oral microbiota in the month prior to inclusion; * having undergone oral surgical treatment within 3 months prior to inclusion; * wearing orthodontic appliances; * having undergone periodontal procedures in the month prior to inclusion; * suffering from severe chronic pathologies deemed incompatible with study entry; * allergic to one of the swab components; * allergic to any of the components of the BUCCOTHERM mouthwash or the placebo; * on drugs that may cause gingival hypertrophy, such as Hydantoins (phenytoin), Dihydropyridines, Diltiazem or Ciclosporin; * Medications that can cause gingival bleeding (anticoagulants, antiplatelet agents and aspirin); * Antibiotic therapy or professional scaling in the month prior to inclusion; * having used oral or topical antibiotics, antiseptics and/or antifungals (e.g., mouthwash, dental gels, etc.) in the month prior to inclusion. * Subjects with poor written and spoken French language skills; * previously included in the BUCCOTHERM study; * simultaneously participating in another trial that may interfere with the conduct of the BUCCOTHERM study or in a period of exclusion after participation in another clinical study; * protected persons (adults under legal protection (legal guardianship, curatorship, tutorship), persons deprived of liberty, pregnant or breastfeeding women, women of childbearing age without effective contraception (estrogen-progestin treatments, IUD, tubal ligation), minors.