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Para-aortic Prophylactic Irradiation for Locally Advanced Cervical Cancer
Sponsor: Zhejiang Cancer Hospital
Summary
Para-aortic lymph node metastasis is a poor prognostic factor for locally advanced cervical cancer, but false negative diagnosis is easy to occur. The aim of this trial was to investigate whether para-aortic prophylactic radiotherapy improves disease-free survival in patients with positive pelvic lymph nodes below the common iliac artery.
Official title: Para-aortic Prophylactic Irradiation for Locally Advanced Cervical Cancer: a Prospective, Randomized, Multicenter Study
Key Details
Gender
FEMALE
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
455
Start Date
2021-08-02
Completion Date
2030-08-01
Last Updated
2022-01-25
Healthy Volunteers
No
Conditions
Interventions
Paraaortic prophylactic irradiation and pelvic definitive concurrent chemoradiation
The para-aortic area, from left renal vein level to abdominal aorta bifurcation level,will be prophylactic irradiation. The other intervention is the same as control arm.
Pelvic definitive concurrent chemoradiation
Pelvic definitive concurrent chemoradiation, including external beam radiotherapy, concurrent chemotherapy and brachytherapy.
Locations (7)
Zhejiang Cancer Hospital
Hangzhou, Zhejiang, China
The First Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, China
Jinhua Municipal Central Hospital Medical Group
Jinhua, China
Lishui People's Hospital
Lishui, China
Ningbo First Hospital
Ningbo, China
Taizhou Central Hospiatl
Taizhou, China
Chongqing University Three Gorges Hospital
Wanzhou, China