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RECRUITING
NCT04974346
PHASE3

Para-aortic Prophylactic Irradiation for Locally Advanced Cervical Cancer

Sponsor: Zhejiang Cancer Hospital

View on ClinicalTrials.gov

Summary

Para-aortic lymph node metastasis is a poor prognostic factor for locally advanced cervical cancer, but false negative diagnosis is easy to occur. The aim of this trial was to investigate whether para-aortic prophylactic radiotherapy improves disease-free survival in patients with positive pelvic lymph nodes below the common iliac artery.

Official title: Para-aortic Prophylactic Irradiation for Locally Advanced Cervical Cancer: a Prospective, Randomized, Multicenter Study

Key Details

Gender

FEMALE

Age Range

18 Years - 75 Years

Study Type

INTERVENTIONAL

Enrollment

455

Start Date

2021-08-02

Completion Date

2030-08-01

Last Updated

2022-01-25

Healthy Volunteers

No

Conditions

Interventions

RADIATION

Paraaortic prophylactic irradiation and pelvic definitive concurrent chemoradiation

The para-aortic area, from left renal vein level to abdominal aorta bifurcation level,will be prophylactic irradiation. The other intervention is the same as control arm.

RADIATION

Pelvic definitive concurrent chemoradiation

Pelvic definitive concurrent chemoradiation, including external beam radiotherapy, concurrent chemotherapy and brachytherapy.

Locations (7)

Zhejiang Cancer Hospital

Hangzhou, Zhejiang, China

The First Affiliated Hospital, Zhejiang University School of Medicine

Hangzhou, China

Jinhua Municipal Central Hospital Medical Group

Jinhua, China

Lishui People's Hospital

Lishui, China

Ningbo First Hospital

Ningbo, China

Taizhou Central Hospiatl

Taizhou, China

Chongqing University Three Gorges Hospital

Wanzhou, China