Clinical Research Directory

Inclusion Criteria: * ≥ 19 years. * Patients who received HBO within 24 hours for acute CO poisoning. * Patients who meet the definition of ASCOP (Patients incapable verbal obey after HBO). * Signed informed consent prior to study entry. Exclusion Criteria: * Cardiac arrest before HBO * Previous neurocognitive disorders * Life-threatening underlying disease (ex: advanced cancer) * Evidence of co-ingestion of sedative or hypnotics confirmed by intravenous flumazenil administration or history taking at the emergency department * Absolute contraindication for TH (active severe bleeding and profound shock not controlled by vasoactive drugs) * No admission * The significant co-ingested drug levels, which are alter the consciousness, is confirmed from the drug analysis lab * Pregnancy * Burns * More than moderate burn or Inhalation burn * Burns complicated by other trauma * Electrical burn * Burns in high risk patients (Patients with chronic underlying diseases (i.e DM, ESRD, liver cirrhosis, etc) which may cause delays or aggravate the wound healing)