Clinical Research Directory

Inclusion Criteria: * Chronic hepatitis B virus infection with documentation at least 6 months prior to screening * Subjects must have been receiving either TAF, TDF (or equivalent), or ETV consistently for ≥12 months prior to dosing Day 1 * HBV DNA \<LLOQ at Screening * HBsAg between 100 and 5,000 IU/mL at Screening * Subjects must be HBeAg-negative at Screening * Fibroscan® result of ≤8.5 kPa within 6 months prior to dosing Day 1 * Medically stable based on physical examination, medical history, vital signs, laboratory values, and 12-lead Electrocardiogram (ECG) at screening Exclusion Criteria: * Evidence of co-infection with hepatitis A, C, D or E virus or human immunodeficiency virus (HIV) at screening * History of any clinically significant medical condition associated with chronic liver disease, cirrhosis, evidence of decompensated liver disease, or findings suggestive of hepatocellular carcinoma (HCC) at any time * Contraindications to the use of Peg-IFNα-2a or incapable of self-administration or assisted administration of Peg-IFNα-2a * Previous treatment with an experimental HBV-directed RNA-interference or antisense oligonucleotide product.