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Brain Mechanisms Supporting Cannabis-induced Pain Relief
Sponsor: University of California, San Diego
Summary
The American Academy of Pain Medicine has labeled pain as a "silent epidemic" due to its staggering costs to society (over $500 billion/year) and widespread prevalence (affects over 100 million Americans). Thus, it is imperative to test and validate cost-effective pain therapies. To this extent, cannabis is characterized as one of the most promising therapies to treat a wide spectrum of pain conditions. However, the clinical applicability of cannabis-based pain therapies has been limited due to lacking mechanistic characterization in human-focused studies. Of critical importance, the neural mechanisms supporting cannabis induced pain relief remain unknown. The primary objective of the proposed pilot study is to identify the brain mechanisms supporting the direct alleviation of acutely evoked pain through vaporized cannabis.
Key Details
Gender
All
Age Range
21 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2021-05-07
Completion Date
2027-03-15
Last Updated
2024-01-08
Healthy Volunteers
Yes
Conditions
Interventions
Active Cannabis
400 mg of vaporized and inhaled active cannabis (5.1%)
Placebo Cannabis
400 mg of vaporized and inhaled placebo cannabis (\<.1%)
Locations (2)
Altman Clinical and Translational Research Institute
La Jolla, California, United States
University of California, San Diego
San Diego, California, United States