Clinical Research Directory

Molecular Profiling in Prostate Cancer

Sponsor: Hellenic Cooperative Oncology Group

Summary

We aim to employ targeted DNA NGS to evaluate the prevalence of germline and somatic mutations in cancer predisposing genes, such as BRCA1 and BRCA2, and other HR and DDR genes, including also a few additional clinically relevant genes, in patients with metastatic, locally advanced or high-grade prostate cancer. In addition, we will investigate the prognostic role of these mutations as well as their association with various clinicopathological parameters. This will be the first study investigating the prevalence of germline and somatic pathogenic mutations in Greek patients with prostate cancer.

Official title: Prognostic and Predictive Value of Tumor Molecular Alterations in Patients With Prostate Cancer

Key Details

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Interventions

Locations (1)